Archives Italiennes de Biologie, 149: 247-255, 2011.
Electroacupucture and nerve growth factor: potential clinical applications
L. MANNI1, M.L. ROCCO1, S. BARBARO PAPARO2, M. GUARAGNA2
1 CNR - National Research Council of Italy, Cell Biology and Neurobiology Institute, Rome, Italy; 2 II Facoltà di Medicina e Chirurgia, Dip. Medicina Interna, U.O. Allergologia e Immunologia Clinica, Università degli Studi “La Sapienza”, Rome, Italy
AbSTRAcT
The nerve growth factor (NGF) is a neurotrophin regulating the survival and function of peripheral sensory and sympathetic neurons and of forebrain cholinergic neurons. Both peripheral neuropathies and brain cholinergic dysfunctions could benefit from NGF-based therapies, but the clinical use of NGF has been so far hampered by the development of important side effects, like hyperalgesia and autonomic dysfunctions. Acupuncture is a therapeutic technique and is a part of traditional Chinese medicine. Western descriptions of the clinical efficacy of acupuncture on pain, inflammation, motor dysfunction, mood disorders, and seizures are based on the stimulation of several classes of sensory afferent fibers and the consequent activation of physiological processes similar to those result- ing from physical exercise or deep massage. Recently, it has been shown that peripheral sensory stimulation by electro-acupuncture (EA) could improve brain NGF availability and utilization, at the same time counteracting the major side-effects induced by NGF administration. This review focuses on the emerging links between EA and NGF with special emphasis on the work carried out in the last decade in our laboratory, investigating the role of NGF as a mediator of EA effects in the central nervous system and as a modulator of sensory and autonomic activity.




Neurosci Lett. 2013 May 18. pii: S0304-3940(13)00447-3. doi: 10.1016/j.neulet.2013.05.026. [Epub ahead of print]
Acupuncture suppresses reinstatement of morphine-seeking behavior induced by a complex cue in rats.
Lee BH, Lim SC, Jeon HJ, Kim JS, Lee YK, Lee HJ, In S, Kim HY, Yoon SS, Yang CH.
Source
Department of Acupuncture, Moxibustion and Acupoint, College of Oriental Medicine, Daegu Haany University, Daegu 706-828, South Korea. Electronic address: dlqhdgy@dhu.ac.kr.
Abstract
Morphine causes physical and psychological dependence for individuals after repeated-use. Above all, our previous study showed that acupuncture attenuated reinstatement of morphine-seeking behavior induced by pharmacological cue. In this study, we investigated whether acupuncture could suppress the reinstatement of morphine-seeking behavior induced by the combination of environmental and pharmacological cues and the possible neuronal involvement. Male Sprague-Dawley rats were trained to self-administer morphine (1.0mg/kg) for 3 weeks. Following the withdrawal phase (7 days), the effects of acupuncture on reinstatement of morphine-seeking behavior were investigated. For the investigation of neuronal involvement, the GABAA receptor antagonist bicuculline and the GABAB receptor antagonist SCH 50911 were pre-treated. Morphine-seeking behavior induced by combination of re-exposure to the operant chamber and morphine injection was suppressed perfectly by acupuncture at SI5, but not at the control acupoint LI5 and this effect was blocked by pre-treatment with the GABA receptor antagonists. This study suggests that acupuncture at SI5 can be considered as a predominant therapy for the reinstatement of morphine-seeking behavior in humans.
Copyright © 2013. Published by Elsevier Ireland Ltd.




Complement Ther Clin Pract. 2014 Feb;20(1):26-31. doi: 10.1016/j.ctcp.2013.10.009. Epub 2013 Nov 5.
A randomized controlled trial of electroacupuncture at body acupoints and Fenglong for regulating serum lipids in dyslipidemic patients in Thailand.
Rerksuppaphol L1, Rerksuppaphol S2.
Author information


Abstract
The primary objective of this randomized, controlled, open-label study was to compare the efficacy of body acupuncture and Fenglong method in controlling serum lipids in patients with dyslipidemia in Thailand. Patients were randomized into two treatment groups (body acupuncture and Fenglong) and a control group. By the end of intervention period, serum lipid level in both treatment groups was significantly lower than its baseline value while in the control group serum lipid levels significantly increased during the same period. At follow-up visit, total cholesterol and LDL cholesterol were significantly lower in both treatment groups when compared to the control group. The effect of both acupuncture interventions was seen in both obese and non-obese patients. In conclusion, body acupuncture and Fenglong method have a positive impact on the regulation of serum lipids that is sustained after the treatment regardless of patient's baseline weight.
Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Acupuncture therapy, Body acupuncture, Dyslipidemia, Fenglong





Variations in energy metabolism along the pericardium meridian and its relationship with visceral function adjustments during electroacupuncture.
Zheng SX, Pan XH, Xu JS1, Xiu CY, Dong YQ, Zhu X.
Author information:
1Fujian Academy of Traditional Chinese Medicine, Class III Laboratory of Acupuncture Physiology, Key Unit of the Propagated Sensation along Meridian of State Administration of Traditional Chinese Medicine, Fuzhou Fujian 350003, China. xujinsenjls@163.com.
Abstract
BACKGROUND:
Electroacupuncture (EA) is a traditional Chinese medicine treatment guided by meridian theory. As it gradually gains more worldwide acceptance, a clarification of its mechanisms is extremely urgent. We observed variations in transcutaneous oxygen pressure/carbon dioxide pressure (tcpO2/tcpCO2) and microcirculation blood perfusion units (BPU) along the pericardium meridian, and cardiac function during EA at Neiguan (PC6) to explore variations in energy metabolism and its relationship with visceral function adjustments during EA.
METHODS:
Twenty-two healthy volunteers participated in this study. Three channel laser Doppler flowmetry and tcpO2/tcpCO2 detection systems were used to detect tcpO2/tcpCO2 and microcirculation BPU along the pericardium meridian. A hemodynamic monitor was used to detect cardiac function.
RESULTS:
In the normal state, the microcirculatory BPU along the pericardium meridian were significantly higher than that of their bilateral corresponding control points (p < 0.05). During EA at PC6, the values of the microcirculatory BPU along the pericardium meridian did not vary, and few increased. In the normal state, the values of tcpO2 along the pericardium meridian were significantly higher than those of their bilateral corresponding control points (p < 0.05). In addition, the values of tcpCO2 along the pericardium meridian were lower than those of their bilateral corresponding control points. In comparison with the normal state, EA could decrease tcpO2 along the meridian significantly (p < 0.05) and increase tcpCO2. During EA at PC6 in healthy volunteers treated by artificial acute mild hypoxia, cardiac output and cardiac index (p < 0.05) decreased and systemic vascular resistance increased significantly (p < 0.05).
CONCLUSIONS:
In the normal state, the values of microcirculatory BPU and tcpO2 along the pericardium meridian were both higher than those of their bilateral corresponding control points. Energy metabolism was vigorous along the meridian. During EA, the decrease in oxygen partial pressure along the pericardium meridian might be a result of strengthened energy metabolism of associated tissue and increased oxygen consumption. The variations in energy metabolism along the pericardium meridian during the course of EA had a close relationship with visceral function adjustments.
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BMC Complement Altern Med. 2014 Aug 30;14:323. doi: 10.1186/1472-6882-14-323.